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Protocols


Transplant Protocols

  • 01-0923 A Study of Hematopoietic Stem Cell Transplantation (HSCT) in Non-Malignant Disease Using a Non- Myloablative Preparatory Regime with Campath-1H, Fludarabine and Melphalan
  • CTN 0501 Double vs. Single Umbilical Cord Blood Transplants
  • CTN 0601 Unrelated Donor Hematopoietic Cell Transplantation for Children with Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen
  • AAML05P1 Killer Immunoglobulin-like Receptor (KIR) Incompatible Unrelated Donor Hematopoietic Cell Transplantation (HCT) for Refractory and Relapsed Acute Myelogenous Leukemia (AML) and Newly Diagnosed AML with Monosomy 7 or -5/5q- in Children: A Children’s Oncology Group (COG) Study
  • ACNS0333 Treatment of Atypical Teratoid/Rhabdoid Tumors (AT/RT) of the Central Nervous System with Surgery, Intensive Chemotherapy, and 3-D Conformal Radiation 
  • ACNS0334 A Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children <36 Months Old with Intensive Induction Chemotherapy with Methotrexate Followed by Consolidation with Stem Cell Rescue vs. the Same Therapy Without Methotrexate
  • AEWS0331 European Ewing Tumor Working Initiative of National Groups Ewing Tumor Studies 1999 (EURO-E.W.I.N.G.99)
  • ANBL0532 Phase III Randomized Trial of Single vs. Tandem Myeloablative as Consolidation Therapy for High-Risk Neuroblastoma
  • PBMTC NMD091 A Pilot Trial of Unrelated Donor Hematopoietic Cell Transplantation for Children with Severe Thalassemia Using a Reduced Intensity Conditioning Regimen (URTH Trial)

Standard Treatment

  • Autologous
    • Total Body Irradiation/Etoposide/Cytoxan
    • Fractionated Total Body Irradiation/Cytoxan
    • Carmustine/Etoposide/Ara-C/Cytoxan
    • Carmustine/Ara-C/Etoposide/Melphalan
    • Busulfan/Cytoxan
    • Melphalan/Etoposide/Carboplatinum
    • Melphalan (1)
    • Melphalan (2)
    • Etoposide/Thiotepa/Cytoxan
    • Carboplatin/Thiotepa/Etoposide
  • Allogeneic
    • Total Body Irradiation/Etoposide/Cytoxan
    • Busulfan/Cytoxan
    • High Dose Cytoxan
    • Fractionated Total Body Irradiation/Cytoxan
    • Single Dose Total Body Irradiation
    • Fludarabine/Busulfan
    • Fludarabine/Cytoxan
    • Fludarabine/Melphalan
    • Fludarabine/Melphalan/ATG (1)
    • Fludarabine/Melphalan/ATG (2)
    • Cytoxan/ATG

Additional Protocols

  • 06-0097 Documenting Speech and Language Impairment in Pediatric Oncology Patients with Sensorineural Loss
  • CIBMTR 06-DON A Multicenter Study of Hematopoietic Stem Cell Donor Safety and Quality of Life
  • ANBL0032 Phase III Randomized Study of Chimeric Antibody 14.18 (Ch14.18) in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue
  • ASCT0631 A Phase III Randomized Trial of G-CSF Stimulated Bone Marrow vs. Conventional Bone Marrow as a Stem Cell Source in Matched Sibling Donor Transplantation
  • ASCT0631D A Comparison of Acute and Long-term Toxicities in Bone Marrow Donors With and Without G-CSF Treatment Prior to Harvest: A Companion Study to ASCT0631

Future Protocols

  • CIBMTR 09-MRD/PBMTC ONC 1001 The Role of Minimal Residual Disease Testing Before and After Hematopoietic Cell Transplantation for Pediatric Acute Myeloid Leukemia 
  • CTN 0801 A Phase II/III Randomized, Multicenter Trial Comparing Sirolimus Plus Prednisone, Sirolimus/Extracorporeal Photopheresis Plus Prednisone, and Sirolimus/Calcineurin Inhibitor Plus Prednisone for the Treatment of Chronic Graft-versus-Host Disease
  • CTN0802 A Multi-Center, Randomized, Double Blind Phase III Trial Evaluating Corticosteroids with Mycophenolate Mofetil vs. Corticosteroids with Placebo as Initial Systemic Treatment of Acute GVHD

St. Louis Children's Hospital is affiliated with Washington University School of Medicine.

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