Overview
Addison disease is when the adrenal glands don't make enough of two steroid hormones. The hormones are cortisol and aldosterone. Cortisol controls the body's metabolism, blocks inflammatory reactions, and affects the immune system. Aldosterone manages sodium and potassium levels. The adrenal glands sit on top of the kidneys. There is one gland on top of each kidney. Addison disease is fairly rare and may first appear at any age.
Causes
The most common cause of Addison disease is damage to the adrenal glands caused by an autoimmune disease. Other cases of Addison disease are caused by the damage to the glands by any of these:
- Cancer
- Infection
- An autoimmune problem
- A rare genetic disease
In rare cases, Addison disease is passed down in a family.
Other causes of low corticosteroids can include:
- Use of corticosteroid medicine. This includes prednisone. The medicines lower the amount of natural corticosteroids made by the adrenal glands.
- Use of some medicines to treat fungal infection. These medicines may stop corticosteroids being made in the adrenal glands.
Risk Factors
A child is at risk for Addison disease if he or she has any of these:
- An autoimmune disease
- Cancer
- Infection such as tuberculosis
- Family history of the disease
- History of using corticosteroid medicine
- History of using anti-fungal medicine
Symptoms
Mild symptoms may only occur when a child is under physical stress. Symptoms may include:
- Muscle weakness
- Fatigue
- Dizziness
- Fast pulse
- Dark skin, first seen on hands and face
- Black freckles
- Bluish-black color around the nipples, mouth, rectum, scrotum, or vagina
- Weight loss
- Dehydration
- Loss of appetite
- Intense salt craving
- Muscle aches
- Nausea
- Vomiting
- Diarrhea
- Intolerance to cold
The symptoms of Addison disease can be like other health conditions. Make sure your child sees his or her healthcare provider for a diagnosis.
Diagnosis
The healthcare provider will ask about your child’s symptoms and health history. He or she may also ask about your family’s health history. He or she will give your child a physical exam. Your child may have blood tests. These are done to check corticosteroid and potassium levels.
Treatment
The goal of treatment is to replace the hormones and to relieve the symptoms. Addison disease can be life-threatening. Because of this, treatment often starts right away with corticosteroid medicine. This medicine may be taken by mouth. Or it may be given by IV. It depends on how sick your child is. In most cases, corticosteroid medicine must be taken for life. Treatment may also include a medicine that helps manage the body's levels of sodium and potassium.
Complications
If left untreated, Addison disease may lead to:
- Severe abdominal pain
- Extreme weakness
- Low blood pressure
- Kidney failure
- Shock from dehydration
Severe complications are most likely to occur when the child is under physical stress.
Lack of adrenal hormones may also cause:
- High blood levels of potassium, which affect the water and sodium levels in the body
- Extreme sensitivity to the hormone insulin, which may lead to low blood sugar levels
Living with
Addison disease is a life-long condition. It needs lifetime treatment. Stressful events such as surgery, infection, or injury can cause severe symptoms of Addison. This is because corticosteroids help the body fight infection and keep healthy during physical stress. Talk with your child’s healthcare provider if your child needs surgery. Get medical care for your child right away if he or she:
- Has vomiting or diarrhea
- Has any other infection or illness
Your child should wear a medical alert bracelet or necklace. Managing your child’s chronic illness can be stressful for all members of the family. Let your healthcare provider know if you, your child with Addison disease, or other family members need help dealing with the physical, emotional, and financial issues that the illness can cause.
When to Call a Healthcare Provider
Call your child's healthcare provider if your child has any symptoms of Addison disease.
If your child has Addison disease, talk with your child’s healthcare provider if your child needs surgery. Get medical care for your child right away if he or she:
- Has vomiting or diarrhea
- Has any other infection or illness
Key Points
- Addison disease is when the adrenal glands don't make enough cortisol and aldosterone.
- Addison disease is a life-long condition. It needs lifetime treatment.
- The most common cause of Addison disease is damage to the adrenal glands caused by an autoimmune disease.
- Mild symptoms of Addison disease may only appear when a child is under physical stress. Symptoms may include muscle weakness, fatigue, and dizziness.
- Addison disease can be life-threatening. Because of this, treatment often starts right away with corticosteroid medicine.
- If left untreated, Addison disease may lead to severe weakness, kidney failure, and shock.
- Stressful events such as surgery, infection, or injury can cause severe symptoms of Addison. Get medical care for your child right away if he or she has vomiting or diarrhea or other illness.
- Let your healthcare provider know if you, your child with Addison disease, or other family members need help dealing with the physical, emotional, and financial issues that the illness can cause.
Next Steps
Tips to help you get the most from a visit to your child’s healthcare provider:
- Know the reason for the visit and what you want to happen.
- Before your visit, write down questions you want answered.
- At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you for your child.
- Know why a new medicine or treatment is prescribed and how it will help your child. Also know what the side effects are.
- Ask if your child’s condition can be treated in other ways.
- Know why a test or procedure is recommended and what the results could mean.
- Know what to expect if your child does not take the medicine or have the test or procedure.
- If your child has a follow-up appointment, write down the date, time, and purpose for that visit.
- Know how you can contact your child’s provider after office hours. This is important if your child becomes ill and you have questions or need advice.
