Joshua B Rubin, MD, PhD
Oncology-Pediatric - certified
*Pediatrics - certified
St. Louis Children's Hospital
For Patients:
To request an appointment, call 800.678.KIDS (5437) or fill out our online form.
For Referring Physicians:
To refer a patient, call Children's Direct at 800.678.HELP (4357).

Suite 9S
Saint Louis, MO 63110
314.454.6018
Education
Internship: Boston Children's Hospital
Residency: Boston Children's Hospital
Fellowship: Dana Farber Cancer Institute
Health Plans Accepted
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Admar |
Aetna HMO/Open Access |
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Aetna Managed Choice POS |
Aetna PPO |
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BCBS of IL PPO |
BCBS/Anthem(Blue Access Choice PPO |
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BCBS/Anthem(Blue Access PPO) |
Beech Street/Capp Care PPO |
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Cigna Open Access HMO/POS |
Cigna PPO |
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CMR (Care Management Resources) |
Community Care Network PPO |
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CorVel PPO |
Coventry Advantra HMO - Medicare |
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Coventry HMO/POS |
Coventry PPO |
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First Health |
Great-West HMO/POS |
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Great-West Open Access |
Great-West PPO |
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Health Alliance HMO & PPO |
Healthlink Open Access/HMO/POS |
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Healthlink PPO |
Home State-MC+ |
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Humana PPO/ChoiceCare Network |
Illinois Public Aid/Health Connect |
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Mail Handlers/CNA PPO |
Medicaid MO/ Missouri HealthNet |
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Medicare |
Mercy Health Plan HMO/POS |
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Mercy Health Plan PPO |
MO Medicaid Secondary to Medicare |
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MultiPlan PPO |
PPO Next/HealthStar |
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Primrose Tertiary/Quarternary |
Private Health Care Systems PPO |
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ProAmerica PPO |
Providers Network of America |
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Tricare/Triwest Prime HMO/POS |
Tricare/Triwest Standard/ Extra PPO |
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Union Pacific RR Emp. Health System |
United Healthcare Choice/Choice+ |
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United Healthcare PPO/ Options |
United Healthcare Select/Select+POS |
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United Payors & Provider |
USA Managed Care Org |
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Wellborn HMO |
Suppression of G protein-coupled Receptor Kinase 3 expression is a feature of Classical GBM that is required for maximal growth.Woerner BM, Luo J, Brown KR, Jackson E, Dahiya SM, Mischel PS, Benovic J, Piwnica-Worms D, Rubin JB.Mol Cancer Res. 2011 Nov 15. [Epub ahead of print]
- PMID:
- 22086906
- [PubMed - as supplied by publisher]
Related citationsCXCR4 activation defines a new subgroup of Sonic Hedgehog driven Medulloblastoma.Sengupta R, Dubuc A, Ward S, Yang L, Northcott P, Woerner BM, Kroll K, Luo J, Taylor MD, Wechsler-Reya RJ, Rubin JB.Cancer Res. 2011 Nov 3. [Epub ahead of print]
- PMID:
- 22052462
- [PubMed - as supplied by publisher]
Related citationsOligodendrogliomas in children.Creach KM, Rubin JB, Leonard JR, Limbrick DD, Smyth MD, Dacey R, Rich KM, Dowling JL, Grubb RL Jr, Linette GP, King AA, Michalski JM, Park TS, Perry A, Simpson JR, Mansur DB.J Neurooncol. 2012 Jan;106(2):377-82. Epub 2011 Aug 13.
- PMID:
- 21842314
- [PubMed - in process]
Related citationsTreating brain tumors with PDE4 inhibitors.Sengupta R, Sun T, Warrington NM, Rubin JB.Trends Pharmacol Sci. 2011 Jun;32(6):337-44. Epub 2011 Mar 28.
- PMID:
- 21450351
- [PubMed - indexed for MEDLINE]
Related citationsGlioblastoma in children: a single-institution experience.Perkins SM, Rubin JB, Leonard JR, Smyth MD, El Naqa I, Michalski JM, Simpson JR, Limbrick DL, Park TS, Mansur DB.Int J Radiat Oncol Biol Phys. 2011 Jul 15;80(4):1117-21. Epub 2011 Jan 8.
- PMID:
- 21220190
- [PubMed - indexed for MEDLINE]
Related citationsPostoperative imaging surveillance in pediatric pilocytic astrocytomas.Dorward IG, Luo J, Perry A, Gutmann DH, Mansur DB, Rubin JB, Leonard JR.J Neurosurg Pediatr. 2010 Oct;6(4):346-52.
- PMID:
- 20887107
- [PubMed - indexed for MEDLINE]
Related citationsHighlights from the latest articles in glioma immunotherapy.Goldhoff P, Rubin JB.Immunotherapy. 2010 Jan;2(1):9-12. No abstract available.
- PMID:
- 20635886
- [PubMed]
Free ArticleRelated citationsCXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice.Sun T, Gianino SM, Jackson E, Piwnica-Worms D, Gutmann DH, Rubin JB.J Neuroimmunol. 2010 Jul 27;224(1-2):108-13.
- PMID:
- 20554030
- [PubMed - indexed for MEDLINE]
Free PMC ArticleRelated citationsCyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1.Warrington NM, Gianino SM, Jackson E, Goldhoff P, Garbow JR, Piwnica-Worms D, Gutmann DH, Rubin JB.Cancer Res. 2010 Jul 15;70(14):5717-27. Epub 2010 Jun 15.
- PMID:
- 20551058
- [PubMed - indexed for MEDLINE]
Free PMC ArticleRelated citationsRadiation therapy for pilocytic astrocytomas of childhood.Mansur DB, Rubin JB, Kidd EA, King AA, Hollander AS, Smyth MD, Limbrick DD, Park TS, Leonard JR.Int J Radiat Oncol Biol Phys. 2011 Mar 1;79(3):829-34. Epub 2010 Apr 24.
- PMID:
- 20421157
- [PubMed - indexed for MEDLINE]
Related citationsBrainstem glioma presenting as pruritus in children with neurofibromatosis-1.Darken RS, Bogitch R, Leonard J, Perry A, McKinstry RC, Gutmann DH, Rubin JB.J Pediatr Hematol Oncol. 2009 Dec;31(12):972-6.
- PMID:
- 19935099
- [PubMed - indexed for MEDLINE]
Related citationsMorphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons.Sengupta R, Burbassi S, Shimizu S, Cappello S, Vallee RB, Rubin JB, Meucci O.J Neurosci. 2009 Feb 25;29(8):2534-44.
- PMID:
- 19244528
- [PubMed - indexed for MEDLINE]
Free PMC ArticleRelated citationsOnly in congenial soil: the microenvironment in brain tumorigenesis.Rubin JB.Brain Pathol. 2009 Jan;19(1):144-9. Review.
- PMID:
- 19076779
- [PubMed - indexed for MEDLINE]
Related citationsTargeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression.Goldhoff P, Warrington NM, Limbrick DD Jr, Hope A, Woerner BM, Jackson E, Perry A, Piwnica-Worms D, Rubin JB.Clin Cancer Res. 2008 Dec 1;14(23):7717-25.
- PMID:
- 19047098
- [PubMed - indexed for MEDLINE]
Free PMC ArticleRelated citationsChemokine signaling in cancer: one hump or two?Rubin JB.Semin Cancer Biol. 2009 Apr;19(2):116-22. Epub 2008 Oct 17. Review.
- PMID:
- 18992347
- [PubMed - indexed for MEDLINE]
Free PMC ArticleRelated citationsFeasibility of small animal cranial irradiation with the microRT system.Kiehl EL, Stojadinovic S, Malinowski KT, Limbrick D, Jost SC, Garbow JR, Rubin JB, Deasy JO, Khullar D, Izaguirre EW, Parikh PJ, Low DA, Hope AJ.Med Phys. 2008 Oct;35(10):4735-43.
- PMID:
- 18975718
- [PubMed - indexed for MEDLINE]
Free PMC ArticleRelated citationsTargeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling X, Frolova O, Levis M, Rubin JB, Negrin RR, Estey EH, Konoplev S, Andreeff M, Konopleva M.Blood. 2009 Jun 11;113(24):6215-24. Epub 2008 Oct 27.
- PMID:
- 18955566
- [PubMed - indexed for MEDLINE]
Free PMC ArticleRelated citationsUse of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma.Frei-Jones M, McKinstry RC, Perry A, Leonard JR, Park TS, Rubin JB.J Neurosurg Pediatr. 2008 Aug;2(2):125-9.
- PMID:
- 18671617
- [PubMed - indexed for MEDLINE]
Free PMC ArticleRelated citationsRethinking brain tumors: the fourth Mouse Models of Human Cancers Consortium nervous system tumors workshop.Reilly KM, Rubin JB, Gilbertson RJ, Garbow JR, Roussel MF, Gutmann DH.Cancer Res. 2008 Jul 15;68(14):5508-11. No abstract available.
- PMID:
- 18632599
- [PubMed - indexed for MEDLINE]
Free PMC ArticleRelated citationsPreclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma.Hegedus B, Banerjee D, Yeh TH, Rothermich S, Perry A, Rubin JB, Garbow JR, Gutmann DH.Cancer Res. 2008 Mar 1;68(5):1520-8.
- PMID:
- 18316617
- [PubMed - indexed for MEDLINE]












