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Protocols

Transplant Protocols

  • 01-0923 A Study of Hematopoietic Stem Cell Transplantation (HSCT) in Non-Malignant Disease Using a Non- Myloablative Preparatory Regime with Campath-1H, Fludarabine and Melphalan
  • CTN 0501 Double vs. Single Umbilical Cord Blood Transplants
  • CTN 0601 Unrelated Donor Hematopoietic Cell Transplantation for Children with Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen
  • AAML05P1 Killer Immunoglobulin-like Receptor (KIR) Incompatible Unrelated Donor Hematopoietic Cell Transplantation (HCT) for Refractory and Relapsed Acute Myelogenous Leukemia (AML) and Newly Diagnosed AML with Monosomy 7 or -5/5q- in Children: A Children’s Oncology Group (COG) Study
  • ACNS0333 Treatment of Atypical Teratoid/Rhabdoid Tumors (AT/RT) of the Central Nervous System with Surgery, Intensive Chemotherapy, and 3-D Conformal Radiation 
  • ACNS0334 A Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children <36 Months Old with Intensive Induction Chemotherapy with Methotrexate Followed by Consolidation with Stem Cell Rescue vs. the Same Therapy Without Methotrexate
  • AEWS0331 European Ewing Tumor Working Initiative of National Groups Ewing Tumor Studies 1999 (EURO-E.W.I.N.G.99)
  • ANBL0532 Phase III Randomized Trial of Single vs. Tandem Myeloablative as Consolidation Therapy for High-Risk Neuroblastoma
  • PBMTC NMD091 A Pilot Trial of Unrelated Donor Hematopoietic Cell Transplantation for Children with Severe Thalassemia Using a Reduced Intensity Conditioning Regimen (URTH Trial)

Standard Treatment

  • Autologous
    • Total Body Irradiation/Etoposide/Cytoxan
    • Fractionated Total Body Irradiation/Cytoxan
    • Carmustine/Etoposide/Ara-C/Cytoxan
    • Carmustine/Ara-C/Etoposide/Melphalan
    • Busulfan/Cytoxan
    • Melphalan/Etoposide/Carboplatinum
    • Melphalan (1)
    • Melphalan (2)
    • Etoposide/Thiotepa/Cytoxan
    • Carboplatin/Thiotepa/Etoposide
  • Allogeneic
    • Total Body Irradiation/Etoposide/Cytoxan
    • Busulfan/Cytoxan
    • High Dose Cytoxan
    • Fractionated Total Body Irradiation/Cytoxan
    • Single Dose Total Body Irradiation
    • Fludarabine/Busulfan
    • Fludarabine/Cytoxan
    • Fludarabine/Melphalan
    • Fludarabine/Melphalan/ATG (1)
    • Fludarabine/Melphalan/ATG (2)
    • Cytoxan/ATG

Additional Protocols

  • 06-0097 Documenting Speech and Language Impairment in Pediatric Oncology Patients with Sensorineural Loss
  • CIBMTR 06-DON A Multicenter Study of Hematopoietic Stem Cell Donor Safety and Quality of Life
  • ANBL0032 Phase III Randomized Study of Chimeric Antibody 14.18 (Ch14.18) in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue
  • ASCT0631 A Phase III Randomized Trial of G-CSF Stimulated Bone Marrow vs. Conventional Bone Marrow as a Stem Cell Source in Matched Sibling Donor Transplantation
  • ASCT0631D A Comparison of Acute and Long-term Toxicities in Bone Marrow Donors With and Without G-CSF Treatment Prior to Harvest: A Companion Study to ASCT0631

Future Protocols

  • CIBMTR 09-MRD/PBMTC ONC 1001 The Role of Minimal Residual Disease Testing Before and After Hematopoietic Cell Transplantation for Pediatric Acute Myeloid Leukemia 
  • CTN 0801 A Phase II/III Randomized, Multicenter Trial Comparing Sirolimus Plus Prednisone, Sirolimus/Extracorporeal Photopheresis Plus Prednisone, and Sirolimus/Calcineurin Inhibitor Plus Prednisone for the Treatment of Chronic Graft-versus-Host Disease
  • CTN0802 A Multi-Center, Randomized, Double Blind Phase III Trial Evaluating Corticosteroids with Mycophenolate Mofetil vs. Corticosteroids with Placebo as Initial Systemic Treatment of Acute GVHD