Periodic fever syndromes refer to diseases that cause periodic (episodic) fever that do not have an infectious (virus/bacteria) cause. Many of these syndromes are hereditary and result from mutation (defect or mistake) in a gene. The syndromes are defined by several factors including:

  • Gene defect
  • Clinical features of the syndrome
  • Parts of the body affected in addition to the fever
  • Age of child when syndrome starts
  • Ethnicity of the child and parents

Many of these syndromes have a specific treatment, often based on understanding the problem caused by the genetic defect.